Changes in bone formation regulator biomarkers in early axial spondyloarthritis
نویسندگان
چکیده
منابع مشابه
Inflammation, new bone formation and treatment options in axial spondyloarthritis.
How and whether ankylosis is connected with inflammation has been discussed for a long time. There are two major reasons for this debate. First, no effective antiinflammatory treatment was available in the past for ankylosing spondylitis (AS) as salicylates, which have been used to treat inflammatory rheumatic diseases for over 100 years, were not effective. However, the first non-steroidal ant...
متن کاملSerum inflammatory biomarkers fail to identify early axial spondyloarthritis: results from the SpondyloArthritis Caught Early (SPACE) cohort
INTRODUCTION Decreasing the diagnostic delay in axial spondyloarthritis (axSpA) remains a major challenge. Here, we assessed the value of serum inflammatory biomarkers to distinguish early axSpA from other pathologies in a large cohort of patients referred with early back pain. METHODS Serum c reactive protein (CRP), erythrocyte sedimentation rate (ESR) and calprotectin were determined in the...
متن کاملHow to diagnose axial spondyloarthritis early.
BACKGROUND Chronic low back pain (LBP), the leading symptom of ankylosing spondylitis (AS) and undifferentiated axial spondyloarthritis (SpA), precedes the development of radiographic sacroiliitis, sometimes by many years. OBJECTIVE To assign disease probabilities and to develop an algorithm to help in the early diagnosis of axial SpA. METHODS Axial SpA comprises AS and undifferentiated SpA...
متن کاملThe usefulness of bone SPECT/CT imaging with volume of interest analysis in early axial spondyloarthritis
BACKGROUND The role of conventional bone scintigraphy in diagnosing early axial spondyloarthritis (SpA) is yet controversial. Single positron emission computed tomography (SPECT) plus CT is an imaging modality that adds better anatomical information to scintigraphy of the sacroiliac (SI) joint. Our aim was to investigate the usefulness of bone SPECT/CT with volume of interest (VOI) analysis in ...
متن کاملCytokine profiles in axial spondyloarthritis
OBJECTIVES Current studies concentrate on the cytokine network and its role in the pathogenesis of spondyloarthritis (SpA). In this study, we analyzed whether the serum cytokine profile (interleukins: IL-10, IL-11, IL-12, IL-15, IL-17, IL-23 and IL-33) correlates with demographic data, clinical manifestations, disease activity and treatment outcome in a group of patients with axial spondyloarth...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2020
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/keaa296